"Normal" will run GSU-1 and GSU-2 games at proper speed as the game intended, it is the game itself that selects between GSU-1 or GSU-2 (10MHz or 20MHz).
"Fast" will run the GSU FPGA core at maximum speed the SD2SNES FPGA will allow, effectively much faster than any real GSU chip.
On "Fast", games that are clock speed (MHz) sensitive, will run much faster than the developer intended, most noticeable is Star Fox, and Stunt Race FX.
Game that are not clock sensitive like Yoshi's Island or Doom will run properly but without the occasional stuttering in graphical heavy scenes.
It is recommended to leave the GSU speed at "Normal" for authentic experience for all GSU games.