In my collection, all of my disc-based games are stored in CHD format. This spans across Sega's consoles and Sony's. There are two obvious benefits - first is space savings (need smaller storage). The second is time savings (less time to transfer data that's half the size).
In order to make my collection compatible with the Mega Everdrive Pro, I wrote a powershell script to convert CHD back to BIN/CUE. It does its job as expected. The side effect is, in addition to taking more than double the time to copy the decompressed data, I aldo needed a larger Micro SD Card.
SegaCD US Collection - 38.7GB (CHD) 68.6 (BIN/CUE)
Utilizing CHD would save on time and space, and eliminate the need to keep two files to run a game.
Discuss. 😊